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Siberian Mouse Hd 132 20

Lin, Q. Y., Jin, L. J., Cao, Z. H., Lu, Y. N., Xue, H. Y., and Xu, Y. P. Acanthopanax senticosus suppresses reactive oxygen species production by mouse peritoneal macrophages in vitro and in vivo. Phytother.Res 2008;22(6):740-745. View abstract.

siberian mouse hd 132 20

Yim, S, Jeong JuCheol, and Jeong JiHoon. Effect of an extract of Acanthopanax senticosus on restoration of hair loss in mouse. Chung-Ang Journal of Medicine Seoul: Institute of Medical Science, Chung-Ang University College of Medicine 2007;32(4):81-84.

Eschbach LF, Webster MJ, Boyd JC, et al. The effect of siberian ginseng (Eleutherococcus senticosus) on substrate utilization and performance. Int J Sport Nutr Exerc Metab 2000;10:444-51. View abstract.

ortho-Aminoazotoluene (o-AT) is a potent hepatocarcinogen for most mouse strains. Previously, it has been shown that oAT administration activates the aryl hydrocarbon receptor (Ahr) and the constitutive androstane receptor (Car) in the mouse liver. Both receptors are directly involved in hepatocarcinogenesis. In this study, we investigated the effect of chronic o-AT administration on the mRNA expression levels of Ahr, Car, and their target genes Cyp1a1 and Cyp2b10, as well as the correlation of their expression with the degree of inflammatory response in the mouse strains DD/He (DD) and CC57BR/Mv (BR), which are contrasting in their sensitivity to hepatocarcinogenesis. Male mice of both strains received the o-AT oil solution at a dose of 225 mg/kg body weight four times within two months. Control animals received the equivalent solvent amount. The mice were sacrificed after 1 and 4 days since the last o-AT administration. The gene expression levels in the liver were determined by real-time PCR. The inflammatory response was evaluated by the serum concentration of the tumor necrosis factor alpha (TNFα). In resistant BR mice, the o-AT administration induced a more pronounced and prolonged increase in the Cyp1a1 mRNA, indicating the preferential Ahr activation in these animals. At the same time a more pronounced increase in the Cyp2b10 expression level in the sensitive DD mice was observed, suggesting the Car activation. In addition, a strong and prolonged inflammatory response to o-AT administration was noted in the DD mice, but not in BR. It is assumed that the prevalence of the Ahr signaling pathway activation over the Car signaling pathway activation is a factor of the resistance to o-AT-induced hepatocarcinogenesis.

The expression of genes Sox2, Klf4, Myc, Sall4, Gata6, Foxa2, Hnf4a, Cdx2, Esrrb, Hand1 in cell lines, embryos and organs of adult voles Microtus rossiaemeridionalis was studied. High resemblance of the expression patterns of these genes in the organs of adult voles, mice and humans was demonstrated. It was established that genes Gata6, Foxa2 and Hnf4a were specifically expressed in vole extraembryonic endoderm cells, while Cdx2 and Hand1 genes, in trophoblast stem cells. This shows that these genes can be used as markers of corresponding vole cell lines. Indirect confirmation pointing to the fact that Oct4 gene is a marker gene for epiblast cells both in the vole and mouse was obtained.

IIJIMA M, NIKAIDO T, AKIYAMA M, MORIYA T, SHIBATA S: Methamphetamine-induced, suprachiasmatic nucleus-independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse. Eur J Neurosci, 16(5):921-9, 2002.

NIKAIDO T, AKIYAMA M, MORIYA T, SHIBATA S: Sensitized increase of period gene expression in the mouse caudate/putamen caused by repeated injection of methamphetamine. Mol Pharmacol, 59(4):894-900, 2001.


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